I have found that to get both velocity and accuracy, this is a pretty good technique:
1. Select your best load with a fairly temp insensitive powder, of approp burn rate. This would include H4895, RL15, and H4350.
2. Stick to a hard cup primer. This will include CCI, W-W, and Rem, at least, maybe others.
3. Pick your best load from three powders, and increase until casehead expansion says stop.
4. Now adjust seating depth [starting from 0.050 clear] carefully until you have the most accurate load w/o pressure signs. Reduce load if you run into them.
5. At most accurate seating depth, adjust powder charge to get best velocity.
6. This is not foolproof, be careful!. If you are really dedicated, do it for all three powders.

Hope this will at least give you someplace to start. If you hate all the results, get a new Kreiger barrel installed by a really good smith.

Good Luck!