I've used Partitions at up to 3300 fps muzzle velocity and had no problems on shots under 100 yards. They do destroy more tissue than some other controlled-expansion bullets, but that's why they kill well.
Have found the 150-grain .270 to work fine on elk and moose, and also on antelope, whitetails, mule deer, caribou and various African plains game, including the notoriously tough gemsbok and blue wildebeest.
