There was a time when that was all I did, and did it just fine. I'm talking back in the 1980s, when I carried a Model 65 S&W with a three inch bull barrel and round butt frame. Back then I was on a kick about only carrying and only shooting Magnums in it, and I had no problem with it. Sure, It starts to get painful after fifty or so rounds, but that was about all I shot on a range trip anyway at that time. No trouble at all keeping them in the kill zone out to fifteen yards.

It all depends on the gun, of course, as an alloy J-Frame in .357 Magnum is just about impossible to shoot well, due to the inevitable flinching you will develop from the pain.