I reached that conclusion about the .22-250 long ago, shortly after plastic-tipped bullets appeared--but also dislike it on PD's due to recoil. It's much easier to spot your own shots through the scope with a smaller round, and being able to spot your shots results in more hits.
These days there are far better solutions, but I still see shooters from other parts of the country bringing .22-250's to their first PD shoot--and (usually) learning the same lessons. One I took PD shooting a couple years ago brought ONLY a .22-250, so I brought along several other rifles he could try. The next year he left the .22-250 at home and brought a brand-new .17 Hornet, and had great fun.
A little lesson I pointed out to John a few years back...