I've got a Savage 12FV in .22-250 that is nearing the end of its barrel life. It use to shoot 40 gr. ballistic tips into tiny little groups using IMR4064 at 4000 fps. but groups are starting to open up. I think the twist is 1 in 14. It absolutely hates anything over 50 gr. and in fact won't stabilize 55 grainers. I have some targets with keyholed bullet holes to prove it.

I have been using it to shoot ground squirrels out to around 300 yards. I'm going on a prairie dog shoot early next summer and am looking to rebarrel it before then in a better long range chambering, something that can reach out a few hundred yards further and not get blown around as much.

The obvious choice is .243 win and put a brake on it so I can actually see hits.

Are there other chamberings I should be considering?