The 270 Tsx is a great choice. I can usually match it with a Hornaday or some other softer bullet. For whatever reason the 375 is very good at throwing different bullets into the same group. I have shot 235 grain, 250,260,270 and 300 grain bullets into nice round groups under two inches edge to edge. This was a mix of off hand, standing and sitting bench so is a workable group for me. I am sure others could do better. My ideal combo would be a 270 Woodleigh for the first shot and the 270 TSX for any follow up shots. The RN will usually not exit on Buffalo the PPSN will more often.
Why the mix? On the trip where I used 270 grain TSX bullets in my .375 RUM I had excellent results on animals from Jackal and Steenbok to Kudu and Eland and at ranges of 30 to 350 yards. I like to keep it simple.
