I thought we settled the fed vs state powers in 1865.
If you are having trouble understanding federal/states powers issues, I suggest you read the constitution!
It's quite clear.
While being personally opposed to legalizing pot (or other drugs) the 10th amendment should prevent the feds from interfereing with drug use laws within a state. The Fed govt has only those powers specifically granted it by the constitution. This is clearly a states rights issue.
Immigration laws are specifically granted to the feds. States have no say or control over any immigration issues. In fact, if state/city officials interfere with immigration enforcement they are quite probably committing a felony.
