I recently bought a pound of RL16 to try in my 280. I tried a load of 51.5 grs, which according to Alliant is max, with a 154 SST bullet. Load shot well under MOA at 100 yds. Actually it was .416! I've also tried in my 7-08 with really good results as well.
I'm interested in whether anyone else has tried RL16 in their 280 Rem, and if so, but what has been your results?