Shoot at what?

Targets?
Varmints?
Big game?

Please do not make the (all too common) mistake of thinking accuracy is what's needed to kill big game and ignore straight line penetration with good weight retention. The 243 fires small bullets as compared to many other calibers and a good bullet that holds together is more important the smaller you get. it is far more capable then many think, but bullets matched to the game is also more important.