Yes, the 6.5 Creed has plenty of the "right stuff" for caribou, even a big bull shot through the lungs is dead bull. My wife and I will be hunting caribou for a few days starting tomorrow and we are using the 6.5 Creed and 127 grain Barnes LRX bullets. If we bump a griz I will use it on the griz also. I will have my .338 Winny along, but it is a back up rifle on this trip.
Every year many caribou are killed with the .243 Win. and the .223 Rem. The Mini 14 and AR platform are popular caribou choices in rural Alaska.
