The information (warning) at the bottom of a quickload data result.......applies to all loads found everywhere, and often SEEMS to be ignored in some posts online and it's a big one.
The variations in powders alone make it important to start lower and work up.
My 2 cents.
See one below.
"Results caused by ± 10% powder lot-to-lot burning rate variation using nominal charge
Data for burning rate increased by 10% relative to nominal value:
+Ba 87 25.00 1695 1754 30806 3379 98.4 1.473 ! Near Maximum !
Data for burning rate decreased by 10% relative to nominal value:
-Ba 87 25.00 1500 1374 21581 3117 85.2 1.725"
God Bless