As an example, I tried to use the 25 yard sight-in method the oldtimers told me about ~35 years ago. Caliber was 30-06 with 180g factory loads. The, scope was a Leupold 3-9x40 mounted as low as possible. Dead on at 25 yards resulted in 8" high at 100 yards. A friend who had a 300 WBY said he experienced the same thing.