I have a .450 Marlin in a Browning BLR. I like both.
I handload, Speer 350, Barnes Original( can't remember bullet weight) and 325 grain ftx's.
The ftx's are not a sturdy bullet and Hornady doesn't recommend the for well- sure shoot well.
The .450 performs identically to a juiced 45/70 on game, imo. It is a superior design though. The case is thicker walled and webbed and more appropriate for higher pressures. Safer, imo and this is why I switched.
It is very easy to deform the 45/70 case by simply dropping it.
Hope this helps- I haven't seen the need to go heavier than a 350 grain bullet.Cheers