223 and lots of ammo. If your not a hand loader Fiocchi loads the vmax and they are cheap and shoot decent enough IME.
I have had the best luck on cloudless full sun days and right after the sun comes up. This time of day they are clustered up and you can get doubles and triples fairly easily. Although latter in the year they seem to get active latter in the morning.
I have never seen a 22LR work worth a damn on prarie dogs.
As other noted PD's are noise sensitive and also movement sensitive. If they are dumb and havent been shot you can get away driving around the town and mowing them down from the truck. The majority of the time you will do better with a portable bench tucked into cover or at least cover behind you to break up your silhouette.

Last edited by BWalker; 07/24/19.