I have a relative with a Bad Bull smokeless ML. He kills elk with it . They are more powerful than a 375 H&H. They cost a lot. But are a serious rifle. He says 350 is a chip shot with it. I just looked and they cost north of 5K.
I looked into them a couple of years ago and there are a couple of people doing conversions off Remington 700 SA rifles for a little more than 1K. I opted for a better breechplug and firing pin for the rifle I had to shoot BH209 out of my 700 ML.