I make up one load that fits in the tightest chamber and call it good. The approach works for us for .223/5.56, .243, .308 Win, .30-06 and .308 Norma which are all I have duplicate chamberings that I load for.
In the cases where I have a chamber that is noticeably tighter than its peers that rifle is the more accurate of them as well.
There's nothing wrong about doing that. Up side is you don't have to pay much attention to the ammo box's. That the way factory ammo is made, one size fit's all!
