I killed one a bit over 300 yards with a 55 gr. Nosler solid base. It ran about 100 yards before it fell and left no blood trail. Expansion and internal damage were obviously much reduced by the low remaining velocity at that range. A sleeker bullet that expands easily like the 77 gr. Sierra TMK would likely do much better at longer range. These days I stick with the 55 gr. Hornady sp as it has proven deadly on a bunch of deer for me over the years and limit the range to 200 yards.