Shoot them just about anywhere from the armpit to the eyeball and it’s game over. I kill at least %90 of my pigs with a 223 and rarely even get a runner let alone one getting away. I have used bullets from 40 to 77 grains on them and noticed no huge difference in effectiveness among them. In fact 40gr Varmeggeddons kill like lightening bolts with chest shots of normal sized pigs.