Two friends with a 270 and 06 respectively, can't remember the bullet weights (I think Sierra is offering only one TGK for each caliber currently), on 2 pronghorns, 1 deer, and 2 elk, all shots exited, all were one shot kills. One elk was shot through both shoulders at ~250 yds. All critters were mostly broadside. From what they told me and from what I have read it sounds as though the TGK is small on expansion and big on penetration. My friends also mention the bullets were very accurate.
I'm kind've interested in what a 140 TGK in my 270 would do on a quartering away elk, but I've pretty much decided I'm going with a 160 NPt next year for the fun of it.
My experience, including the old X-Bullets that sometimes didn't seem to expand, when there is an exit hole the critter gets obviously sick and doesn't go far.