The .22-250 is a classic coyote killer. I don't have experience with 40 gr. bullets, but 55 & 60 grain bullets are pure poison on coyotes. If you shoot the shoulder you might tear a bigger hole in the hide. Combine high velocity and bones and it's not great on hides.

Every normal man must be tempted, at times, to spit on his hands, hoist the black flag, and begin slitting throats.