When I was a kid my neighbor shot a guy breaking into his shop behind his house. He shot him in the knee with a 22 mag Ruger single six, they had to amputate the dudes leg.
the ruger single six is the sweet spot handgun for 22wmr. my 5.5” rss shoots 22wmr like a laser, way more accurate than i deserve and is fun too. even handgun barrel specific 22wmr ammo really needs a 5”ish minimum barrel to do well, imho. a rss is in my get-home bag. 100 rounds each of 22wmr/lr is highly portable, and since i can reliably hit with both rimfire ammos, is more efficient for me than a heavier caliber.
