4227 is easy on older guns, reportedly preferred by Hank Williams, Jr., a big time Colt collector and shooter.
It works very well in my 24" Marlin Cowboy .45 Colt with 300 gr. bullets, both jacketed and cast. Evidently 4227 has a smooth pressure curve, not a sharp peak.
Now, just for target loads, Red Dot is hard to beat, very accurate and consistent.
DF