and truthfully who knows? We have transitioned from 54 caliber bullets in handguns, to the norm now about 35 caliber. It is impossible to find anything logical other than big solid bullets are needed to penetrate through a buffalo. The 22LR is probably the most lethal cartridge in the world based on people being shot dead with it, OTOH the vagaries of human reaction to being shot are infinitely varied. Regan was shot with a 22 and did not know he was even hit, others shot with a 22 COM react differently. I would not carry a 22LR unless its all I had.