I gave great consideration to it when I bought my first left handed rifle. It was either going to be a 300 H&H or an 8mm Remington Magnum. I ended up with a 300 H&H in a LH KS Mountain Rifle. No regrets. I had a lot of brass for the 300 and a good stock pile of bullets. I would have like to have played with 8mm but there always seemed there was another rifle or chambering that was catching my interest. A couple of acquaintances have them and have killed a lot of deer, elk and moose with them and a few bears. I honestly don't know what they use for bullets. Neither have ever complained of a failure.
I had just graduated for high school when that Shooting Times magazine came out heralding the arrival of the 8mm Magnum. I was a poor farm kid saving my nickels for college but nearly swooned over Remington's newest round. Even back then I liked the odd and unusual chamberings.
It seems I have always had the ground the 8mm covers pretty well bracketed. 300 H&H, 35 Whelen, 375 H&H. I guess that's why I never had a 338 WM, 340 Wby, or 358 Norma though I've flirted with the idea many times. Those three and the 8mm RM can certainly do it all for NA big game.