I have to go eat dinner. I hope I did not make any mistakes....  
My worst case scope screws:Looking at Quickload my 6 pound 10 ounce BAR 338WM shooting 250 gr  Nos Part Gold 3.34" 69 gr H4350 QL predicts 66kpsi 2595 fps, chrono measures 2645 fps.
QL calculates the bullet accelerate from 500 fps to 1500 fps in 0.2 ms during peak pressure.   acceleration = 250 gr 1000 fps /0.2 ms=1.25 EE6
The center of mass of the gas would accelerate half the distance, so half the acceleration of the bullet. mv = 69 gr 500 fps/0.2 ms= 1.725 EE5
The mass the scope adds to the rifle would reduce scope acceleration and gas mass acceleration would increase, so I will drop both as roughly cancelling each other out.

The rifle velocity is [bullet velocity] [bullet mass]/ [rifle mass]=  V bullet [ 250 /7000 grains/pound]/6.6 pounds= .0054 bullet velocity
The rifle accelerates  at a rate of 1000 fps /0.2 ms [0.0054] = 5.4 fps /0.2ms= 27000 fps^2
https://www.calculatorsoup.com/calculators/physics/force.php
For a 1 pound scope that is 839 pounds of force
For a 2 pound scope, that is 1678 pounds of force  

  A #6 screw tightened to 18 inch pounds with dry threads will make 640 pounds of clamping force.
With 4 screws this is 2560 pounds of clamping force.
If there is no oil between the receiver and scope bases, the coefficient of friction is 0.8. That would be good for up to 2048 pounds of scope acceleration force.
But if there is oil, then the coefficient of friction is 0.16 and only good for up to 409 pounds of scope acceleration force, and the scope zero will be lost.  

There is nothing noble in being superior to your fellow man; true nobility is being superior to your former self. -Ernest Hemingway
The man who makes no mistakes does not usually make anything.-- Edward John Phelps