Really depends on what varmint shooting you are doing and if you care about pelt damage or not. For me something that fires a 120-140 grain bullet and another that shoots a 165-200 is a nice combo. You can pick your level of recoil but I like light weight rifles for hunting so a 7-08 and 30-06 will do the job. Either of these will serve as a backup for one another in a pinch.