I wouldn't worry about it unless there's news of Interstate's being blocked in St Louis,...which is unlikely. The way the interstate is configured in Louisville and St Louis, you don't pass through much "city". You can see a bit of ghetto from I-70 going through St Louis, but you don't get very close to it. St Louis is one of the easier big cities to get through. Kansas City is a bit more troublesome. Louisville can get fairly backed up during certain hours of the day. But I haven't been there since they completed the improvements on I-64. Traffic might flow more easily now.
