I've never been a 180/308 guy. I've always used 150's and 165's. I took my biggest whitetail, a 200lb (dressed) 4x4 with a 150 Speer HotCore (in and out). Also took my biggest elk, an old mature 7x7, with the 165 Hotcore. The last elk I shot (or latest :)) was with a Hornady 165 SP Interlock. It broke the big upper leg bone of the 6x6, penetrated both lungs, and was in the offside ribs.

“Perfection is Achieved Not When There Is Nothing More to Add, But When There Is Nothing Left to Take Away” Antoine de Saint-Exupery