I have thin smallish hands and the factory Python grips are awful to me, somewhat akin to grasping a railroad tie. The smaller, what S&W would call a Magna or really more like a Service stock are much better. Add a Tyler T or a Pachmyer grip adapter and they become downright useable, again for me.

FWIW I also despise S&W Targets aside from the early Coke bottle profile stocks that cost as much as a decent M10 if you can find a set. All of the later iterations of Targets are much too large and angular for me.