I bought an 8lb jug of IMR4350 military surplus a few years ago. Loaded up some for my newest toy, a 308 Remington. I used 42grn of the IMR4350 and 168grn bullets. Shot one round and the bolt locked up. got it opened and the brass had no primer and I never found it. Fortunately it didn't burn the face of the bolt. I don't know why and I never fired anymore of that load. After thoroughly cleaning the bore and chamber I fired a 3 shot group with the same bullet and 43 grns of BLC-2. It shot a .4" group and no pressure signs.
Don't know if it was missed packaged or what. First time I tried it and the jug was sealed.