At one time, I had a .45-70 Guide gun and a .44 Mag rifle, both loaded with 300 grain bullets.
I still have the .45-70, but a friend had to have the .44 Mag., a Ruger 77/44.
The reason for the 300 grainers in the .45-70 was recoil, I had been in a pretty severe vehicle accident that injured my neck and shoulders and it was very painful to fire my usual load, a Beartooth PileDriver Jr at just under 1700 fps.
