These posts scare me. For decades I had assumed that the pre'64 Model 70--the rifleman's rifle--was the pinnacle of bolt actions except maybe for the Weatherby MkV. The only one I have left is a .375 which I load under maximum., With a magnum like that you don't need the last fps of velocity.
I had a batch of 6XC (formed from resizing and fire forming 22-250 cases) that I reloaded 30 times, trying to see how long cases lasted. The load was (calculated at) only 42,000 psi. I thought the failure would be loose primer pockets or split necks. It never occured to me it might be case separation.