I have used them in 3006 on a moose at about 100 yards and it worked fine. About 70 or 71% retained weight. I shot 3 times 2 exited but one was still in the moose against hide on far side. I had wanted to use nosler partitions but they wouldn't shoot accurately in my gun so I used these. I talked to Ed Matunis who worked for winchester and he advised me that they were designed for 300 H&H velocities i.e. 2880, I also read a lot of Finn Aagard who used the 270 gr power point on lion and liked it. I figured if these two guys used winchester bullets and liked them I could use them on a deer or moose. I was not disappointed. I also used the 150 gr power point from at the same gun on deer and it worked perfectly,although I always got complete penetration.