Mostly that it can jack pressures to an unsafe level. That being said, I am loading them for a Ruger Super Redhawk, which is built like a tank. I appreciate the input. Most of my loading has been for rifles, so the magnum pistol world is a little foreign still to me. It is good to hear real world experiences from guys that have been there and done it. I ended up loading up 23 grains of H110 behind a 240 grain Hornady with a Federal Large Magnum Pistol Primer to start at. I took that load from Ken Water's book that he loaded for the exact gun that I am shooting. In the book he states that is "near a max load". Made me feel more comfortable about the load. I have also shot Buffalo Bore +P cast loads through this gun with absolutely zero issues. Yet again, I feel more comfortable seeking a bit of guidance from those more experienced when I am in doubt, so thank you again for the input guys!