Larger diameter. That’s 22 thousandths larger. I personally don’t think that’s significant for in application. Hunting, target, or self defense.
That’s saying the .243 is the same as the 6.5, and the 6.5 is equal to the 7mm, etc. (.244-.264-.284-.308). I find those to be significant steps.
The only point in bringing reloading into the conversation is that the 45 Colt is a BAD choice if you don’t reload. The 44 is far more versatile off the shelf.