Would like to add my 2 cents here. I live at 1300 feet here in South Dakota and shot my elk at 10,600 feet last November. Did some serious exercising before the hunt and got myself into shape. Stayed hydrated and started taking Diamox 2 days before the hunt started. I received a kidney transplant in 2008 and take blood pressure and anti-rejection medications as well but the doctors at Mayo Clinic said the Diamox would not interact with any of my meds. I quit drinking pop (soda) several years ago but bought a six-pack of small Coke cans to celebrate when I shot my elk. That was the worse can of Coke I ever had! I forgot that Diamox makes carbonated beverages taste quite nasty and I will attest to that!