No HS-6 fans?!
You all are going to break John Linebaugh's heart!
For the moment, HS-6 is the powder of choice for my Redhawk 45 Colt. I didn't jump into the conversation because I don't yet have enough experience with the powder to be able to say it falls into the "all around powder" category. But...for what I want to do with my rig - and that's push a 255gr. SWC to moderate or a half step above moderate - so far HS-6 has beaten both Universal and Unique for me.
