WHB,
Your Ruger in .405 WCF looks like a well balanced and fast handling rifle and yes the Hornady 300 grain ammo makes fast work of most big game. I used that on all deer sized game and handloaded North Fork 300 grain for Nilgai and other tough game.
The use of the 400 grain Woodleigh in Africa was a fun project to see how the 400 grain bullet performed. The answer was very well with no bullets ever recovered, even from buffalo. I am confident that a 400 grain solid would put an elephant down. Heck, a 300 grain NF might take an Ele too.


CRS, NRA Benefactor Life Member, Whittington Center, TSRA, DWWC, DRSS
Android Reloading Ballistics App at http://www.xplat.net/