I've ran my standard 44 Special (Smith 24-3) load through the same (GP/5 incher ) and would not hesitate to run it to 25psi load level, if needed.

It's usually not needed and the NOE 275 Keith (that generally weighs 280 with wheelweight metal) and 8 grs.CFE Pistol is about as much bucking that size gun or a tapered barrel Smith 24 will allow before eating on parts of your hand.