I shoot 150s in my M99 with a peep sight and I shoot 180s in my Remington M81 with factory iron sights. I think the 180 are a bit less accurate then the 150s in the Remington, but only about 1" larger groups are expects, so for a rifle I only shoot to about 200 yards max, the 180s are fine and the do work well on game.
The very 1st elk I ever killed was with my dad's 300 Savage back in the late 60. I used what we bought at the sporting goods counter at a gas station. My dad called them "elk bullets". They were 180s, and I think they were Remington's if I remember correctly. Shot was on a 4X5 bull with spindly horns at about 50 yards but it worked fine.
