There are 2 Slime products
Tubeless -- & Tube type.
NEITHER I have used are pressurized containers.
I had a flat on the front of my 255 Ferguson MAY. 14. I put half a bottle of Slime in it THEN aired up to 35 psi.
Tube type
YES put hole/leak on bottom THEN add slime. Give it a little time to seal.
Still Holding today.