You can and it will...................but the results suck. There is no accuracy and the .22lr cases split or bulge up front. The .22WMR chamber in addition to being longer than the .22lr, is also slightly larger in diameter. Then there's the danger of a squib because of the split and pressure loss, but they usually just rattle down the barrel.
I don't even like .22lr/.22WMR convertible revolvers because the bore diameter has to be a middle-of-the road compromise to accommodate the differences in bullet diameters.They'll both shoot okay, but neither will shoot well. A dedicated .22lr for shooting .22lr, and a dedicated .22WMR for shooting .22WMR, I say. They'll both work out better for you.
THIS
I have a single six with both cylinders, it is acceptably accurate but not great.
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