Unless it a long range application, no need to worry, just load and shoot what is most accurate in your rifle.
That's kind of what I was thinking too. Can't imagine a target much outside 300 yards in an urban type setting. I'm thinking of something like a 110 VMAX, light, fast, flat shooting, and pretty much 100% fragmentation in the target. If I need something for more of a barrier target, I have tons of heavier GMX type rounds already.