On deer size animals I doubt very seriously that you'd notice any difference between the two. I've used Sierra bullets for most of my deer hunting loads over the years, with the various name changes they've gone through. The Sierra Game King bullets always did what they were supposed to do...........as long as I did my part. I do have a bunch of 129 grain Hornady Interlocks that I got in a trade that I want to try in one of my 6.5 CM's. I also have some 140's in 270, as well as some 100 grain 243 Interlocks that have been sitting on the shelf for a number of years. For some reason, I just keep using the Sierra bullets................probably because I know they work.