This is slightly different than you asked, but cast bullets work well with certain fast powders and really do fairly well. An example is I use 12 grains unique in my 358 Win under a 160 grain bullet which propels it to 1650 fps. Some guys do something similar in a 30-06 pushing a 170 grain bullet to maybe 1800 fps. Cast out of lead that is not too brittle and with a hollow point that would be very effective out to 200 yards. So if you are looking purely at powder savings, that would be a viable option.

......the occasional hunter wielding a hopelessly inaccurate rifle, living by the fantastical rule that this cartridge can deliver the goods, regardless of shot placement or rifle accuracy. The correct term for this is minute of ego.