Never felt anything negative. Felt instantly better overnight though a few times. Wife has had it a few times at least, maybe three and bounced back taking it. I didn't have antibodies and didn't test positive for covid or strep when I was sick. It's a good drug for sure. Tractor Supply took it off the shelf for a while when they caught onto so many people taking it. Just how absurd and criminal .gov has been restricting access.