Shaq: I have a BUNCH of Rifles in caliber 22 L.R. that I use for Ground Squirrel/Small Game Hunting using high velocity hollow point ammunition. I sight these in at 100 yards dead on and using "Kentucky Windage" (hold over/hold under) for longer and closer distances.
My 22 L.R. pistols that I use for Small Game and Ground Squirrel Hunting are sighted in at 50 yards.
Hold into the wind
VarmintGuy