Alaska-Yukon moose are the biggest of the breed, and the only ones I've ever shot - 20 something. .243, 30-30, .270, 30-06, .338WM, and 12 ga slugs have all worked. I'm itching to try the .260...or maybe the 7X57.
Shot placement (and good bullet construction- not necessarily premium- which I've gotten away from,) is the key.
Don't over-think it.
