I used to carry a S&W 18, bought it in 1983, but switched to a 422 in 1986 or 1987 and then a 2206 in 2009. The 422 and 2206 carry flatter/closer than the 18. The only thing that I don't like about the 422 family is the location of the cocking indicator pin, as I have dented a couple of walnut stocks on those pins when I carried the pistol in a belt holster.

Good luck finding the .22 handgun that works well for you.