with 75 and 80 grain bullets in a Ruger 22.250, with a 24 inch Pac Nor Stainless barrel, heavy magnum contour, 1 in 7 twist,
I found the fastest velocity and accuracy combination has been a charge of 33.5 grains of IMR 4064, or RL 15 or IMR 4895.
thought 4350 powders or slower would give faster MV, but that turned out to be wrong.
MV with the ones I mentioned above are 3300 fps...